Clinical Prof Peter Bye did his Intern, Resident and General Medicine Registrar training at RPAH. He was seconded to Papua New Guinea for a period of eight months. He then completed his clinical training in Respiratory Medicine in the Page Chest Pavilion and undertook a Phd in “Studies of Exercise and Sleep in Interstitial Lung Disease” at University of Sydney and RPAH. He spent two years as a post Doctoral Fellow in the Meakins–Christie Laboratories, Royal Victoria Hospital, Montreal, Canada and then six months at the Royal Postgraduate Medical School, Hammersmith Hospital London, UK doing research and clinical work. He was then appointed to the staff of the Dept of Respiratory Medicine at RPAH where he is currently Clinical Professor and Senior Staff Specialist. Clinical and Research Positions (See also Research Translation) • Director, Cystic Fibrosis Service at Royal Prince Alfred Hospital.,1986-2012 • Deputy Head of Dept Respiratory Medicine 1990-2010 • Clinical Associate Professor, University of Sydney, 1992,Clinical Professor 2009 • Director of Cystic Fibrosis Research Group, Woolcock Institute 2000-2011 • Member of RPAH Research Committee 1996-2000 • Member of RPAH Quality of Care\ Committee 2002-2012 • Member of Board of Directors, Asthma Foundation of NSW 1998-2004 • Member of Medical Advisory Committee Asthma New South Wales 1984-2010 • . Peer Recognition • Invited speaker at two joint WHO/International CF Association Workshops • Speaker by invitation at the US Cystic Fibrosis Foundation Williamsburg Conference for breaking CF research science in 1999 and 2004.The presentation in 1999 resulted in USCFF funding to A/Prof Bye for ongoing research into Hypertonic Saline as a new treatment for CF. • Australian representative, speaker at North American Cystic Fibrosis Foundation Clinical Trials Meeting. 2000-2008. • Member of Scientific Medical Advisory Committee International Cystic Fibrosis Association, 1996-2002. • Chairperson of Special Interest Group in Cystic Fibrosis for Thoracic Society Australia & NZ 2000-2003. • Member of the Centre for Clinical Research Excellence in Respiratory Diseases at RPAH,.2005-2009 • Member of Database Committee of Cystic Fibrosis Australia – Inauguration 1998 – 2011 Prizes and Awards • Winner of prestigious RPAH Foundation Research Medal 2005. • Research Director & Supervisor to Inaugural Winner Sir Zelman Cowen Prize For Discovery In Medical Research, 2006-Mark Elkins. • Winner of Thoracic Society of Australia and New Zealand Research Medal 2009 • Awarded 50 peer reviewed grants, including 12 NHMRC Project Grants worth a total of five million dollars. • In 1996, the Best Poster Award at the Thoracic Society for Australia and New Zealand was awarded to A/Professor Bye’s PhD student, Michael Robinson, for a major project, namely “The Effect of Increasing Doses of Hypertonic Saline on Mucociliary Clearance in Patients with Cystic Fibrosis” • Presented with Asthma Foundation Award in 1997 in recognition of many years of service( two decades) as Medical Director of the Children’s Annual Holiday Camps. Summary of Original Clinical Research Achievements • Internationally recognised for discovery of beneficial effect of hypertonic saline in improving mucus clearance, lung function, quality of life and reducing respiratory exacerbations in patients with cystic fibrosis.(NEJM 2006) Hypertonic saline is now a standard treatment for cystic fibrosis, already used by 25% of US CF patients (US CFF Database 2007).despite minimal marketing and promotion by any pharmaceutical company. • One of only two non Americans highlighted on North American Cystic Fibrosis Foundation – Expanding the Horizon of Hope: Fifty years of progress in Cystic Fibrosis. (Celebratory DVD) • Described the beneficial effect of oxygen on exercise endurance in interstitial lung disease and respiratory muscle function in normal subjects and patients with COPD. • Described respiratory muscle fatigue following high intensity exercise in normal subjects. • Major research in predictors of sleep disordered breathing, early research of non-invasive ventilation during sleep, comparison of O2 versus NIV during sleep in cystic fibrosi. • Described effect of pulmonary exacerbations in disturbing sleep and impairing neurocognitive function in cystic fibrosis • Original description of physiological responses to upper limb exercise. • Two major North American CF Foundation Grants, including first ever awarded outside the USA. • Finding of widespread clonal strain of Pseudomonas aeruginosa in a number of CF clinics which prompted review of infection control guidelines. • A Chief Investigator in Canada –Australia collaborative study which showed that treatment of pulmonary exacerbations in Cystic Fibrosis directed by Multiple Combination Bacterial Therapy was not superior to standard physician directed therapy.(Lancet 2005).Ongoing studies in bacterial growth and antibiotic resistance in anaerobic and biofilm conditions. Fostering Clinical Research Training and Career Development: • Continuous NHMRC Project Grant support for twenty-two years since 1985. • Awarded 50 peer reviewed grants, worth a total of five million dollars. • 12 NHMRC Project Grants. 10 NHMRC Equipment Grants. • 4 Ramaciotti Foundation Grants. • 15 Cystic Fibrosis Australia Research Trust Grants. • 5 Community Health and Anti-Tuberculosis Association Research Grants. • 2 United States Cystic Fibrosis Foundation Grants. • 2 University of Sydney Sesqui Grants. • 125 publications in peer reviewed journals. • Current associate supervisor to two PhD students. Primary supervisor to seven PhD students, all successfully completed and associate to four students • A Senior Respiratory Fellow, Dr Anju Anand from St Michael’s Hospital Toronto will undertake a Clinical Research Attachment with.A/ Prof Bye in 2009.This will continue and foster his research collaboration with Canada. • Editorial Board, Journal of Cystic Fibrosis, inaugural, 2000-2006. Translation of Clinical Research Findings into Improved Health Care: • Invited speaker at two joint WHO/International CF Association Workshops • Regular invited speaker and invited Chairman at American Thoracic Society, North American Cystic Fibrosis Conference, Biennial Australian Cystic Fibrosis Conference, Thoracic Society of Australia and New Zealand. • Initiated a regular specialist adult respiratory service to Shoalhaven District and provided this for twenty years. • Australian representative, speaker at North American Cystic Fibrosis Foundation Clinical Trials Meeting. 2000-2008. • Member of Standards of CF Care, CF Australia, Steering Committee 2006-2008. Co-author of the chapters, Outpatient Care, Newly Diagnosed Adult • Member of Cystic Fibrosis Centre Directors Group • Initiated development of Australian CF Clinical Practice Guidelines – TSANZ CF SIG. • Member of Database Committee of Cystic Fibrosis Australia – Inauguration – 2008 • Facilitator of Canada-Australia Cystic Fibrosis Research Group.2003 - 2008 • Head, Program Committee – Biennial Australian Cystic Fibrosis Conference, Sydney 1999, Member of Program Committee for 2007 Sydney Conference. • Member of Greater Metropolitan Clinical Taskforce: Transition Care Group 2003-2004 • Member of Greater Metropolitan Clinical Taskforce Respiratory Network: Working Group Meeting-Highly Specialised Diseases and Treatments 2006-2008. • Long term Teacher to Medical Students, Basic and Advanced Trainee Registrars in General and Respiratory Medicine Professional Activities Fulltime involvement in the busy inpatient and consultation roster of the RPAH Department of Respiratory Medicine (30 inpatient beds-often exceeded).Also on the inpatient roster for the Medical Assessment Unit at RPAH Regular Bronchoscopy clinic. Two clinics per week of general respiratory medicine. Director of Adult Cystic Fibrosis Service-currently 250 patients.Often five to ten inpatients .Large Wednesday afternoon and Friday CF outpatient clinics . Ninety two CF patients have undergone bilateral lung transplantation. Organise the Dept of Respiratory Medicine weekly teaching meeting Attend teaching sessions at RPAH, NSW branch of TSANZ, National and International Meetings Assist Prof Young and Dr Mc Namara with reporting of lung function and exercise tests