The microbiome of skin and chronic wounds in type II diabetes — ASN Events
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The microbiome of skin and chronic wounds in type II diabetes (#19)

Catherine Burke 1 , Melissa Gardiner 2 , Elizabeth Harry 2 , Michael Liu 2 , Mauro Viacaretti 3 , Jill Sparks 3 , Aaron Darling 2 4
  1. The ithree institute, University of Technology Sydney, Sydney, NSW, Australia
  2. The ithree institute, University of Technology Sydney, Sydney, NSW, Australia
  3. Podiatry Clinic, Westmead Hospital, Sydney, NSW, Australia
  4. Genome Center, University of California, Davis, CA, United States of America

Type II diabetes is a chronic health condition which is associated with skin conditions including chronic foot ulcers and an increased incidence of skin infections.  The skin microbiome (microbes living on skin) is thought to play important roles in skin defense and immune functioning.  Diabetes affects the skin environment, and this may perturb skin microbiome with possible implications for skin infections and wound healing.  This study examines the skin and wound microbiome in type II diabetes. Ten type II diabetic subjects with chronic foot ulcers were followed over a time course of 12 weeks, sampling from both skin and wounds, with the skin microbiome compared to a control group.  The diabetic skin microbiome showed differences to healthy controls, and chronic wounds were colonized by skin taxa, along with different profiles of microbes in individual patients.  Differences in the skin microbiome may contribute to delayed wound healing in diabetic subjects.

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