The inflammatory response to bacterial pathogens is often the result of the stimulation of pattern recognition receptors by highly conserved bacterial products collectively known as “pathogen-associated molecular patterns”. Although inflammation is most often viewed as a host defense response to combat pathogen infections, for Salmonella Typhimurium the host inflammatory response is required for its replication because essential nutrients and respiration substrates only become available in inflamed intestinal tissues. Consequently, S. Typhimurium has evolved specific adaptations to trigger inflammatory responses in the intestinal track that do not rely on the stimulation of pattern recognition receptors by conserved bacterial products. The nature of these specific adaptations will be discussed.