Genome dynamics provide a rapid mechanism of stress response, yet ultimately chromosomes must be relatively stable.  The non-coding chromosomal components:  centromeres, telomeres and origins of replication are all important for this genome stability.   Centromeres are instrumental in assuring proper chromosome segregation and are likely to play a key role in the missegregation events that lead to aneuploidy as well as shifts in whole genome ploidy.  Origins of replication are thought to be critical for ensuring that genomes are replicated once, and only once, in a given cell cycle and how this is achieved (or ignored in some situations) remains to be understood in pathogenic fungi.  Finally, telomeres, the chromosome ends, are extremely dynamic, with the end sequences extending and eroding continuously. Furthermore, telomere-associated sequence families expand and change very rapidly, providing a major mechanism for rapid adaptation to changing environments.  In this talk I will highlight our understanding of the structure and dynamics of centromeres, origins of replication and telomeres in the fungal pathogen Candida albicans.  Our work has highlighted the flexibility of all three structures and their ability to maintain chromosome integrity despite, or perhaps because of, their dynamic nature